Genetic deletion of microsomal prostaglandin E synthase-1 promotes imiquimod-induced psoriasis in mice

Abstract Background Psoriasis is a chronic inflammatory disease associated with abnormalities in the immune system. Microsomal prostaglandin E synthase-1 (mPGES-1), a terminal enzyme for prostaglandin (PG) E2 biosynthesis, is highly expressed in the skin of psoriasis patients. However, the detailed...

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Auteurs principaux:	Fumiaki Kojima, Yuka Hioki, Miori Sumida, Yoshiko Iizuka, Hitoshi Kashiwagi, Kei Eto, Shiho Arichi, Shotaro Maehana, Makoto Kubo, Haruhito A. Uchida, Takafumi Ichikawa
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2025-06-01
Collection:	Inflammation and Regeneration
Sujets:	Psoriasis Inflammation Immunity Interleukin-17 A Cyclooxygenase Prostaglandin E synthase
Accès en ligne:	https://doi.org/10.1186/s41232-025-00385-2
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