Genetic deletion of microsomal prostaglandin E synthase-1 promotes imiquimod-induced psoriasis in mice

Abstract Background Psoriasis is a chronic inflammatory disease associated with abnormalities in the immune system. Microsomal prostaglandin E synthase-1 (mPGES-1), a terminal enzyme for prostaglandin (PG) E2 biosynthesis, is highly expressed in the skin of psoriasis patients. However, the detailed...

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Detalhes bibliográficos

Principais autores:	Fumiaki Kojima, Yuka Hioki, Miori Sumida, Yoshiko Iizuka, Hitoshi Kashiwagi, Kei Eto, Shiho Arichi, Shotaro Maehana, Makoto Kubo, Haruhito A. Uchida, Takafumi Ichikawa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-06-01
coleção:	Inflammation and Regeneration
Assuntos:	Psoriasis Inflammation Immunity Interleukin-17 A Cyclooxygenase Prostaglandin E synthase
Acesso em linha:	https://doi.org/10.1186/s41232-025-00385-2
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