Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies

A library of novel naproxen based 1,3,4-oxadiazole derivatives (<b>8</b>–<b>16</b> and <b>19</b>–<b>26</b>) has been synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized hybrids, compound2-(4-((5-((<i>S</i>)-1-(2-methoxynaphthalen-6-yl)ethyl)-1,3,4-oxadiazol-2-ylthio)m...

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Bibliografske podrobnosti

Principais autores:	Mohammad Mahboob Alam, Syed Nazreen, Abdulraheem S. A. Almalki, Ahmed A. Elhenawy, Nawaf I. Alsenani, Serag Eldin I. Elbehairi, Azizah M. Malebari, Mohammad Y. Alfaifi, Meshari A. Alsharif, Sulaiman Y. M. Alfaifi
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2021-08-01
Serija:	Pharmaceuticals
Teme:	naproxen 1,3,4-oxadiazole cytotoxicity EGFR computational study
Online dostop:	https://www.mdpi.com/1424-8247/14/9/870
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