Synthesis of New 1, 3, 4-Oxadiazole-Incorporated 1, 2, 3-Triazole Moieties as Potential Anticancer Agents Targeting Thymidylate Synthase and Their Docking Studies

Thymidylate synthase (TS) has emerged as a hot spot in cancer treatment, as it is directly involved in DNA synthesis. In the present article, nine hybrids containing 1,2,3-triazole and 1,3,4-oxadiazole moieties (<b>6</b>–<b>14</b>) were synthesized and evaluated for anticancer and in vitro thymidyla...

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Auteurs principaux:	Mohammad Mahboob Alam, Abdulraheem SA Almalki, Thikryat Neamatallah, Nada M. Ali, Azizah M. Malebari, Syed Nazreen
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2020-11-01
Collection:	Pharmaceuticals
Sujets:	thymidylate synthase cytotoxicity 1,2,3-triazole 1,3,4-oxadiazole 5-fluoruracil pemetrexed
Accès en ligne:	https://www.mdpi.com/1424-8247/13/11/390
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