Remarkable Response of EGFR- and HER2-Amplified Metastatic Colon Cancer to Pyrotinib After Failed Multiline Treatments: A Case Report and Literature Review

Human epidermal growth factor receptor 2 (HER2) has been verified as a valuable biomarker and treatment target in metastatic colorectal cancer (mCRC). Pyrotinib, a novel irreversible HER2/epidermal growth factor receptor (EGFR) dual tyrosine kinase inhibitor, can efficiently inhibit the proliferatio...

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Hlavní autoři:	Hong-Shuai Li, Li-Li Yang, Ming-Yi Zhang, Ke Cheng, Ye Chen, Ji-Yan Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-10-01
Edice:	Frontiers in Oncology
Témata:	colorectal cancer human epidermal growth factor receptor 2 trastuzumab resistance pyrotinib
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2020.548867/full
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