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P110α inhibitor alpelisib exhibits a synergistic effect with pyrotinib and reverses pyrotinib resistant in HER2+ breast cancer

Human epidermal growth factor receptor 2 (HER2) plays a critical role in breast cancer progression in patients with HER2 overexpression, thereby driving the development of targeted drugs and advancing therapy strategies targeting this gene. Pyrotinib is a novel irreversible pan-ErbB kinase inhibitor...

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Principais autores: Hao Chen, Yuhao Si, Jialiang Wen, Chunlei Hu, Erjie Xia, Yinghao Wang, Ouchen Wang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-09-01
Serier:Neoplasia: An International Journal for Oncology Research
Fag:
Her2+ Breast cancer
Pyrotinib
Alpelisib
Synergism
Drug resistant
Online adgang:http://www.sciencedirect.com/science/article/pii/S1476558623000386
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