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Kinetics of HIV-Specific CTL Responses Plays a Minimal Role in Determining HIV Escape Dynamics

Cytotoxic T lymphocytes (CTLs) have been suggested to play an important role in controlling human immunodeficiency virus (HIV-1 or simply HIV) infection. HIV, due to its high mutation rate, can evade recognition of T cell responses by generating escape variants that cannot be recognized by HIV-speci...

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Hlavní autoři: Yiding Yang, Vitaly V. Ganusov
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018-02-01
Edice:Frontiers in Immunology
Témata:
HIV
CTL escape
multiple responses
mathematical model
model fitting
likelihood
On-line přístup:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00140/full
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