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Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome

<p>Abstract</p> <p>Background</p> <p>A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To determine the impact of immune escape mutations selected by cytotoxic T lymphocytes (CTL) on viral fitn...

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Kaydedildi:
Asıl Yazarlar: Song Hongshuo, Pavlicek Jeffrey W, Cai Fangping, Bhattacharya Tanmoy, Li Hui, Iyer Shilpa S, Bar Katharine J, Decker Julie M, Goonetilleke Nilu, Liu Michael KP, Berg Anna, Hora Bhavna, Drinker Mark S, Eudailey Josh, Pickeral Joy, Moody M, Ferrari Guido, McMichael Andrew, Perelson Alan S, Shaw George M, Hahn Beatrice H, Haynes Barton F, Gao Feng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2012-10-01
Seri Bilgileri:Retrovirology
Konular:
Human immunodeficiency virus type I
Viral fitness
Cytotoxic T lymphocytes
Immune escape mutation
Transmitted/founder virus
Mathematical model
Online Erişim:http://www.retrovirology.com/content/9/1/89
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