Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome

<p>Abstract</p> <p>Background</p> <p>A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To determine the impact of immune escape mutations selected by cytotoxic T lymphocytes (CTL) on viral fitn...

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Autori principali:	Song Hongshuo, Pavlicek Jeffrey W, Cai Fangping, Bhattacharya Tanmoy, Li Hui, Iyer Shilpa S, Bar Katharine J, Decker Julie M, Goonetilleke Nilu, Liu Michael KP, Berg Anna, Hora Bhavna, Drinker Mark S, Eudailey Josh, Pickeral Joy, Moody M, Ferrari Guido, McMichael Andrew, Perelson Alan S, Shaw George M, Hahn Beatrice H, Haynes Barton F, Gao Feng
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2012-10-01
Serie:	Retrovirology
Soggetti:	Human immunodeficiency virus type I Viral fitness Cytotoxic T lymphocytes Immune escape mutation Transmitted/founder virus Mathematical model
Accesso online:	http://www.retrovirology.com/content/9/1/89
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