Resistance to immune checkpoint inhibitors in colorectal cancer with deficient mismatch repair/microsatellite instability: misdiagnosis, pseudoprogression and/or tumor heterogeneity?

Colorectal carcinoma (CRC) with deficiency of the deficient mismatch repair (dMMR) pathway/microsatellite instability (MSI) is characterized by a high mutation load and infiltration of immune cells in the tumor microenvironment. In agreement with these findings, clinical trials have demonstrated a s...

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Autores principales:	Nicola Normanno, Vincenza Caridi, Matteo Fassan, Antonio Avallone, Fortunato Ciardiello, Carmine Pinto
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Open Exploration Publishing Inc. 2024-05-01
Colección:	Exploration of Targeted Anti-tumor Therapy
Materias:	colorectal carcinoma deficient mismatch repair microsatellite instability immune checkpoint inhibitors resistance tumor heterogeneity
Acceso en línea:	https://www.explorationpub.com/Journals/etat/Article/1002231
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