Resistance to immune checkpoint inhibitors in colorectal cancer with deficient mismatch repair/microsatellite instability: misdiagnosis, pseudoprogression and/or tumor heterogeneity?

Colorectal carcinoma (CRC) with deficiency of the deficient mismatch repair (dMMR) pathway/microsatellite instability (MSI) is characterized by a high mutation load and infiltration of immune cells in the tumor microenvironment. In agreement with these findings, clinical trials have demonstrated a s...

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Egile Nagusiak:	Nicola Normanno, Vincenza Caridi, Matteo Fassan, Antonio Avallone, Fortunato Ciardiello, Carmine Pinto
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Open Exploration Publishing Inc. 2024-05-01
Saila:	Exploration of Targeted Anti-tumor Therapy
Gaiak:	colorectal carcinoma deficient mismatch repair microsatellite instability immune checkpoint inhibitors resistance tumor heterogeneity
Sarrera elektronikoa:	https://www.explorationpub.com/Journals/etat/Article/1002231
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