USP37 protects mammalian cells during DNA replication stress by counteracting CUL2LRR1 and TRAIP
Summary: The USP37 deubiquitylase is essential for mammalian cells to survive DNA replication stress, but the underlying mechanisms are unknown. Here, we demonstrate that USP37 binds the CDC45-MCM-GINS (CMG) helicase, which forms the stable core of the replisome until DNA replication termination whe...
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| Huvudupphov: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Elsevier
2025-06-01
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| Serie: | Cell Reports |
| Ämnen: | |
| Länkar: | http://www.sciencedirect.com/science/article/pii/S2211124725005108 |
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