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LBX1 alters polyamine pathway in adolescent idiopathic scoliosis – a new therapeutic target to mitigate curve progression

Background: Adolescent idiopathic scoliosis (AIS) is the most common three-dimensional (3D) spinal deformity occurring during puberty, with girls at a higher risk of curve progression to the surgical threshold. Ladybird homeobox 1 (LBX1) is the most promising AIS predisposing gene based on GWAS stud...

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Kaydedildi:
Asıl Yazarlar: Zhe Zhang, Yujia Wang, Zongshan Hu, Wenlin Tian, Mengheng Li, Ziyang Tang, Liang Chang, Hok-him Tang, Gen Tang, Jie Li, Zhichong Wu, Haixia Xu, Elvis Chun-sing Chui, Zhen Liu, Adam Yiu-chung Lau, Tsz-ping Lam, Daniel Kam-wah Mok, Huanxiong Chen, Yong Qiu, Jack Chun-Yiu Cheng, Zezhang Zhu, Wayne Yuk-Wai Lee
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2026-03-01
Seri Bilgileri:Journal of Orthopaedic Translation
Konular:
Adolescent idiopathic scoliosis
Animal model
LBX1
Paraspinal muscle
Polyamine pathway
Translational research
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2214031X26000185
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