Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor
The binding of a drug targeting the active site of a predominantly monomeric SARS-CoV-2 main protease (MProM) favors an equilibrium shift to MProM dimer formation with two equivalent active sites. These results suggest targeting the monomeric active site and/or the dimer interface to interfere with...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Portfolio
2022-03-01
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| Saila: | Communications Biology |
| Sarrera elektronikoa: | https://doi.org/10.1038/s42003-022-03084-7 |
| Etiketak: |
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