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Small protein blockers of human IL-6 receptor alpha inhibit proliferation and migration of cancer cells

Abstract Background Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor (IL-6R) complex is critical in tumor progression and, therefore, IL-6R represen...

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Principais autores: Yaroslava Groza, Lukáš Lacina, Milan Kuchař, Leona Rašková Kafková, Kateřina Zachová, Olga Janoušková, Radim Osička, Jiří Černý, Hana Petroková, Joanna Maria Mierzwicka, Natalya Panova, Petr Kosztyu, Kristýna Sloupenská, Jan Malý, Jozef Škarda, Milan Raška, Karel Smetana, Petr Malý
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-05-01
Colecção:Cell Communication and Signaling
Assuntos:
IL-6
IL-6R blockers
Cancer cell migration
Migrastatics
Malignant melanoma
Pancreatic carcinoma
Acesso em linha:https://doi.org/10.1186/s12964-024-01630-w
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