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The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants

Abstract We investigate the mechanism associated with the severity of COVID-19 in men with TLR7 mutation. Men with loss-of-function (LOF) mutations in TLR7 had severe COVID-19. LOF mutations in TLR7 increased the risk of critical COVID by 16.00-fold (95% confidence interval 2.40–106.73). The deleter...

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Váldodahkkit: Shaik Mohammad Naushad, Gowtham Mandadapu, Mekala Janaki Ramaiah, Fahad N. Almajhdi, Tajamul Hussain
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2023-08-01
Ráidu:Scientific Reports
Liŋkkat:https://doi.org/10.1038/s41598-023-40114-8
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