The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase

DNA glycosylases are lesion-specific enzymes that recognize specific nucleobase damages and catalyze their excision through cleavage of the glycosidic bond. Here, the authors present the crystal structures of human 8-oxoguanine (oxoG) DNA glycosylase bound to undamaged DNA and to DNA containing an i...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Uddhav K. Shigdel, Victor Ovchinnikov, Seung-Joo Lee, Jenny A. Shih, Martin Karplus, Kwangho Nam, Gregory L. Verdine
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2020-09-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-020-18290-2
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!