KDM6B inhibition enhances chemotherapeutic response in small cell lung cancer via epigenetic regulation of apoptosis and ferroptosis

Abstract Background Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid progression and the frequent emergence of resistance to standard chemotherapeutic agents such as cisplatin (DDP) and etoposide (VP16), resulting in poor clinical outcomes. Methods and results T...

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Detalhes bibliográficos

Principais autores:	Zhongliang Wang, Ziyuan Liu, Yufan Yang, Wenyang Wang, Qian Chen, Shumei Liang, Linlang Guo, Man Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	Cell & Bioscience
Assuntos:	Small cell lung cancer Chemotherapy resistance KDM6B KDM6B/ERG3/c-FOS axis Drug combination
Acesso em linha:	https://doi.org/10.1186/s13578-025-01496-6
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