Astaxanthin mitigates cardiac toxicity induced via doxorubicin by alleviating mitochondrial fission and autophagy in rats

Abstract Doxorubicin (DOX)-induced cardiotoxicity is the most prevalent adverse reaction of DOX during chemotherapy and significantly impacts its clinical application. At present, clinical interventions for mitigating DOX-induced cardiotoxicity remain sub-optimal. Mitochondria are the primary target...

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Hlavní autoři:	Yongjing He, Dan Wu, Qianqian Wu, Sisi Huang, Yuansheng Zhan, Jiaqiang Deng, Jing yu Chen, Lu xie, Junhui Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-09-01
Edice:	Scientific Reports
Témata:	Astaxanthin Doxorubicin Cardiotoxicity Mitochondrial dynamics Mitochondria autophagy
On-line přístup:	https://doi.org/10.1038/s41598-025-17253-1
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