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Association study of the GAB2 gene with the risk of developing Alzheimer's disease

The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE ɛ4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD...

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Autori principali: Julien Chapuis, Didier Hannequin, Florence Pasquier, Peter Bentham, Alexis Brice, Isabelle Leber, Thierry Frebourg, Jean-François Deleuze, Emmanuelle Cousin, Uma Thaker, Philippe Amouyel, David Mann, Corinne Lendon, Dominique Campion, Jean-Charles Lambert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2008-04-01
Serie:Neurobiology of Disease
Soggetti:
Alzheimer
GAB2
APOE
Polymorphism
Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996107002835
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