Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways

Missense mutations of ubiquilin 2 (UBQLN2) have been identified to cause X-linked amyotrophic lateral sclerosis (ALS). Proteasome-mediated protein degradation is reported to be impaired by ALS-associated mutations of UBQLN2. However, it remains unknown how these mutations affect autophagy-lysosome p...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Akiko Idera, Lisa M. Sharkey, Yuki Kurauchi, Keiichi Kadoyama, Henry L. Paulson, Hiroshi Katsuki, Takahiro Seki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-07-01
coleção:	Journal of Pharmacological Sciences
Assuntos:	Amyotrophic lateral sclerosis Ubiquilin 2 Chaperone-mediated autophagy Macroautophagy
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1347861323000324
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!