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Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP

Aggregation of misfolded proteins underlie dementias. Here, the authors show that stressed cells activate an innate mechanism to resolve aggregates of defective proteins in the endoplasmic reticulum, where a third of cellular proteins are produced.

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Główni autorzy: Eduardo Pinho Melo, Tasuku Konno, Ilaria Farace, Mosab Ali Awadelkareem, Lise R. Skov, Fernando Teodoro, Teresa P. Sancho, Adrienne W. Paton, James C. Paton, Matthew Fares, Pedro M. R. Paulo, Xin Zhang, Edward Avezov
Format: Artigo
Język:Inglês
Wydane: Nature Portfolio 2022-05-01
Seria:Nature Communications
Dostęp online:https://doi.org/10.1038/s41467-022-30238-2
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