Deciphering the <i>Nodamura virus</i> Protein A Function in <i>Schizosaccharomyces pombe</i> and Engineering a Novel Self-Amplifying RNA (saRNA) Vector NovaVec for Vaccine Development

<b>Background/Objectives:</b> Self-amplifying RNA (saRNA) vectors enable high-level transgene expression from minimal initial doses. While alphavirus-based saRNA systems are widely used, they suffer from limitations, including large genome size, complex replicase machinery, and cellular toxicity. No...

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Detalhes bibliográficos

Principais autores:	Xueyao Song, Ruihan Liu, Zhuo Zhang, Yuying Pan, Wanting Qu, Niubing Zhang, Xuan Li, Xiangping Yao, Pei Hao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-06-01
Colecção:	Vaccines
Assuntos:	self-amplifying RNA (saRNA) <i>Nodamura virus</i> viral replication complex RNA vaccine RNA-dependent RNA polymerase
Acesso em linha:	https://www.mdpi.com/2076-393X/14/6/532
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