Revealing the role of U2AF1 in splicing regulation and chimeric RNA dynamics

Abstract U2 small nuclear ribonucleoprotein auxiliary factor 1 (U2AF1) gene is a pivotal splicing factor frequently mutated in various malignancies, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). U2AF1 plays a critical role in the recognition and processing of 3ʹ splice...

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Principais autores:	Sangeen Khan, Yue Tang, Yangyang Guo, Jing Feng, Hui Wu, Zhenguo Song, Chengjuan Zhang, Fujun Qin
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-05-01
Series:	Scientific Reports
Assuntos:	U2AF1 Mutation Splicing Alternative splicing Chimeric RNA, cis-SAGe RNA-seq
Acceso en liña:	https://doi.org/10.1038/s41598-025-99865-1
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