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Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a

Dysregulated synaptic plasticity is a key feature of neurodevelopmental disorders, including autism. This study investigated whether Fragile X mental retardation protein (FMRP), a selective RNA-binding protein that regulates synaptic protein expression by interacting with miRNAs, mediates the effect...

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Main Authors: Huan Chen, Dan Qiao, Chang Wang, Bohan Zhang, Zhao Wang, Longmei Tang, Yibo Wang, Ran Zhang, Yizhou Zhang, Leigang Song, Hongchun Zuo, Fangzhen Guo, Xia Wang, Sha Li, Huixian Cui
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
androgen
FMRP
synaptic plasticity
PSD95
miR-125a
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.872347/full
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