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Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a

Dysregulated synaptic plasticity is a key feature of neurodevelopmental disorders, including autism. This study investigated whether Fragile X mental retardation protein (FMRP), a selective RNA-binding protein that regulates synaptic protein expression by interacting with miRNAs, mediates the effect...

Täydet tiedot

Tallennettuna:
Päätekijät: Huan Chen, Dan Qiao, Chang Wang, Bohan Zhang, Zhao Wang, Longmei Tang, Yibo Wang, Ran Zhang, Yizhou Zhang, Leigang Song, Hongchun Zuo, Fangzhen Guo, Xia Wang, Sha Li, Huixian Cui
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2022-04-01
Sarja:Frontiers in Cellular Neuroscience
Aiheet:
androgen
FMRP
synaptic plasticity
PSD95
miR-125a
Linkit:https://www.frontiersin.org/articles/10.3389/fncel.2022.872347/full
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