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Peptide Bond Formation between Aminoacyl-Minihelices by a Scaffold Derived from the Peptidyl Transferase Center

The peptidyl transferase center (PTC) in the ribosome is composed of two symmetrically arranged tRNA-like units that contribute to peptide bond formation. We prepared units of the PTC components with putative tRNA-like structure and attempted to obtain peptide bond formation between aminoacyl-minihe...

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Principais autores: Mai Kawabata, Kentaro Kawashima, Hiromi Mutsuro-Aoki, Tadashi Ando, Takuya Umehara, Koji Tamura
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-04-01
Serier:Life
Fag:
tRNA
minihelix
peptide bond formation
ribosomal symmetrical region
proto-ribosome
Online adgang:https://www.mdpi.com/2075-1729/12/4/573
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