FGF-independent MEK1/2 signalling in the developing foetal testis is essential for male germline differentiation in mice

Abstract Background Disrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated with testis cancer in humans. In mice, SRY and SOX9 induce expression of Fgf9, which promotes Sertoli cell differentiation and testis developme...

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Detalhes bibliográficos

Principais autores:	Rheannon O. Blücher, Rachel S. Lim, Ellen G. Jarred, Matthew E. Ritchie, Patrick S. Western
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-12-01
coleção:	BMC Biology
Assuntos:	Germline development MEK1/2 FGF9 Testis Foetal gonad Sex differentiation
Acesso em linha:	https://doi.org/10.1186/s12915-023-01777-x
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