Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Abstract Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide, yet no FDA‐approved anti‐HEV medication available. Elucidating HEV replication machinery is therefore crucial for identifying novel antiviral targets, and consequently developing potent antivirals. The nonstruc...

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Detalhes bibliográficos

Principais autores:	Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-12-01
Colecção:	Advanced Science
Assuntos:	antiviral target hepatitis E virus ORF1 polyprotein replication machinery RNA‐dependent RNA polymerase X domain
Acesso em linha:	https://doi.org/10.1002/advs.202501699
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