Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Abstract Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide, yet no FDA‐approved anti‐HEV medication available. Elucidating HEV replication machinery is therefore crucial for identifying novel antiviral targets, and consequently developing potent antivirals. The nonstruc...

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Váldodahkkit:	Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Wiley 2025-12-01
Ráidu:	Advanced Science
Fáttát:	antiviral target hepatitis E virus ORF1 polyprotein replication machinery RNA‐dependent RNA polymerase X domain
Liŋkkat:	https://doi.org/10.1002/advs.202501699
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