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Mechanistic Insights into Inorganic Nitrite-Mediated Vasodilation of Isolated Aortic Rings under Oxidative/Hypertensive Conditions and S-Nitros(yl)ation of Proteins in Germ-Free Mice

The prevalence and clinical importance of arterial hypertension are still growing. Inorganic nitrite (NO<sub>2</sub><sup>−</sup>) represents an attractive dietary antihypertensive agent, but its metabolism and mode of action, which we aimed to investigate with the present study, are not completely u...

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Main Authors: Paul Stamm, Sanela Kalinovic, Matthias Oelze, Sebastian Steven, Alexander Czarnowski, Miroslava Kvandova, Franziska Bayer, Christoph Reinhardt, Thomas Münzel, Andreas Daiber
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-03-01
Series:Biomedicines
Subjects:
inorganic nitrite
oxidative stress
arterial hypertension
vascular function
metabolism and bioactivation
Online Access:https://www.mdpi.com/2227-9059/10/3/730
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