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Efficacy and immunological correlates of an mRNA-LNP vaccine for protection against an emerging rickettsial pathogen

A rickettsial pathogen, Ehrlichia chaffeensis, causes an emerging tick-borne disease called human monocytic ehrlichiosis (HME). E. chaffeensis in ticks expresses a porin OMP-1B, the immunodominant major outer membrane protein, which is required for nutrient uptake across the outer membrane of bacter...

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Autori principali: Mingqun Lin, Stephen Denton, Nan Duan, Naveed Iqbal, Prosper N. Boyaka, Garima Dwivedi, Mohamad-Gabriel Alameh, Drew Weissman, Yasuko Rikihisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2026-12-01
Serie:Emerging Microbes and Infections
Soggetti:
Ehrlichia
OMP-1B
Rickettsia vaccine
mRNA-LNP
neutralizing antibody
IgG1/IgG2a
Accesso online:https://www.tandfonline.com/doi/10.1080/22221751.2026.2645860
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