Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma

Background & Aims: Mcl-1, an antiapoptotic protein overexpressed in many tumours, including hepatocellular carcinoma (HCC), represents a promising target for cancer treatment. Although Mcl-1 non-apoptotic roles might critically influence the therapeutic potential of Mcl-1 inhibitors, these funct...

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Principais autores:	Laure-Alix Clerbaux, Pierre Cordier, Nina Desboeufs, Kristian Unger, Peter Leary, Gabriel Semere, Yannick Boege, Lap Kwan Chan, Chantal Desdouets, Massimo Lopes, Achim Weber
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2023-10-01
Series:	JHEP Reports
Assuntos:	Liver Polyploidy Mcl-1 Chromosome segregation Mutational signature Hepatocarcinogenesis
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2589555923001696
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