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Enhanced IL-12 transgene expression improves oncolytic viroimmunotherapy

IntroductionMalignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with unacceptably low cure rates occurring often in patients with neurofibromatosis 1 defects. To investigate oncolytic Herpes Simplex Virus (oHSV) as an immunotherapeutic approach, we compared viral replication, f...

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Principais autores: Yeaseul Kim, Uksha Saini, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Xiaokui Mo, Timothy P. Cripe, James Markert, Kevin A. Cassady, Ravi Dhital
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-06-01
Colecção:Frontiers in Immunology
Assuntos:
IL-12
oncolytic herpes simplex virus (oHSV)
malignant peripheral nerve sheath tumor (MPNST)
CD4+ T cells
dendritic cells
Interferon-gamma
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1375413/full
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