Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution

Oncolytic viruses, modified for tumor-restricted infection, are a promising cancer immunotherapeutic, yet much remains to be understood about factors driving their activity and outcome in the tumor microenvironment. Here, we report that oncolytic herpes simplex virus C134, previously found to exert...

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Bibliografski detalji

Glavni autori:	Jack Hedberg, Adam Studebaker, Luke Smith, Chun-Yu Chen, Jesse J. Westfall, Maren Cam, Amy Gross, Ilse Hernandez-Aguirre, Alexia Martin, Doyeon Kim, Ravi Dhital, Yeaseul Kim, Ryan D. Roberts, Timothy P. Cripe, Elaine R. Mardis, Kevin A. Cassady, Jeffrey Leonard, Katherine E. Miller
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2023-09-01
Serija:	Molecular Therapy: Oncolytics
Teme:	oncolytic virus medulloblastoma brain tumors cancer immunotherapy pediatric cancer
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2372770523000505
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