Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution

Oncolytic viruses, modified for tumor-restricted infection, are a promising cancer immunotherapeutic, yet much remains to be understood about factors driving their activity and outcome in the tumor microenvironment. Here, we report that oncolytic herpes simplex virus C134, previously found to exert...

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Autors principals:	Jack Hedberg, Adam Studebaker, Luke Smith, Chun-Yu Chen, Jesse J. Westfall, Maren Cam, Amy Gross, Ilse Hernandez-Aguirre, Alexia Martin, Doyeon Kim, Ravi Dhital, Yeaseul Kim, Ryan D. Roberts, Timothy P. Cripe, Elaine R. Mardis, Kevin A. Cassady, Jeffrey Leonard, Katherine E. Miller
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-09-01
Col·lecció:	Molecular Therapy: Oncolytics
Matèries:	oncolytic virus medulloblastoma brain tumors cancer immunotherapy pediatric cancer
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2372770523000505
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