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Identification and validation of plasma protein biomarkers as therapeutic targets in acute myeloid leukemia: an integrative multi-omics study

IntroductionAcute myeloid leukemia (AML) remains a therapeutic challenge due to its high relapse rate and limited treatment options. This study aimed to identify and validate novel circulating protein biomarkers with causal roles in AML pathogenesis using an integrative multi-omics approach.MethodsW...

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Principais autores: Linhui Hu, Qingqing Luo, Ya Liao, Zhimin Zhai, Yangyang Ding, Yan Fei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-10-01
coleção:Frontiers in Immunology
Assuntos:
acute myeloid leukemia
Mendelian randomization
plasma proteins
therapeutic targets
multi-omics
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1659811/full
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