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Mechanism by which SAHA regulates HLA-E expression via the endoplasmic reticulum stress-related PERK/ATF4/CHOP pathway in neuroblastoma

BackgroundHuman leukocyte antigen E (HLA-E) plays a role in tumor immune escape and is associated with poor prognosis in neuroblastoma (NB). This study aimed to investigate the regulatory effect of suberoylanilide hydroxamic acid (SAHA) on HLA-E expression via the PERK/ATF4/CHOP pathway in NB.Method...

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Principais autores: Zhuoran Li, Xi Zhen, Chenggong Zeng, Yan Mao, Zhiqing Wei, Zijun Zhen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-03-01
Serier:Frontiers in Immunology
Fag:
endoplasmic reticulum stress (ERS)
human leukocyte antigen E (HLA-E)
immune evasion
neuroblastoma
suberoylanilide hydroxamic acid (SAHA)
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1741513/full
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