Mechanism by which SAHA regulates HLA-E expression via the endoplasmic reticulum stress-related PERK/ATF4/CHOP pathway in neuroblastoma

BackgroundHuman leukocyte antigen E (HLA-E) plays a role in tumor immune escape and is associated with poor prognosis in neuroblastoma (NB). This study aimed to investigate the regulatory effect of suberoylanilide hydroxamic acid (SAHA) on HLA-E expression via the PERK/ATF4/CHOP pathway in NB.Method...

Full description

Bibliographic Details

Main Authors:	Zhuoran Li, Xi Zhen, Chenggong Zeng, Yan Mao, Zhiqing Wei, Zijun Zhen
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-03-01
Series:	Frontiers in Immunology
Subjects:	endoplasmic reticulum stress (ERS) human leukocyte antigen E (HLA-E) immune evasion neuroblastoma suberoylanilide hydroxamic acid (SAHA)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1741513/full
Tags:	Add Tag No Tags, Be the first to tag this record!