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Mycobacterium tuberculosis Infection-Driven Foamy Macrophages and Their Implications in Tuberculosis Control as Targets for Host-Directed Therapy

Tuberculosis (TB) is a leading cause of death worldwide following infection with Mycobacterium tuberculosis (Mtb), with 1.5 million deaths from this disease reported in 2018. Once the bacilli are inhaled, alveolar and interstitial macrophages become infected with Mtb and differentiate into lipid-lad...

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Principais autores: Dahee Shim, Hagyu Kim, Sung Jae Shin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-05-01
Serier:Frontiers in Immunology
Fag:
Mycobacterium tuberculosis
foamy macrophage
tuberculosis
immune responses
lipid metabolism
lung inflammation
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2020.00910/full
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