The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis

Inflammatory bowel disease (IBD) patients often exhibit expansion of the gut pathobiont, adherent-invasive E. coli (AIEC). Loss of activity of the IBD susceptibility gene, protein tyrosine phosphatase type 2 (PTPN2), causes gut microbiota dysbiosis in IBD patients, while Ptpn2 knock-out (Ptpn2-KO) m...

Полное описание

Библиографические подробности

Главные авторы:	Pritha Chatterjee, Vinicius Canale, Stephanie J. King, Ali Shawki, Hillmin Lei, Alina N. Santos, Michael Haddad, Casey Gries, Dermot P. B. McGovern, James Borneman, Declan F. McCole
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis Group 2025-12-01
Серии:	Gut Microbes
Предметы:	AIEC LF82 JAK-STAT gut barrier IBD tofacitinib
Online-ссылка:	https://www.tandfonline.com/doi/10.1080/19490976.2025.2526136
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