BDNF/TrkB signalling, in cooperation with muscarinic signalling, retrogradely regulates PKA pathway to phosphorylate SNAP-25 and Synapsin-1 at the neuromuscular junction

Abstract Background Protein kinase A (PKA) enhances neurotransmission at the neuromuscular junction (NMJ), which is retrogradely regulated by nerve-induced muscle contraction to promote Acetylcholine (ACh) release through the phosphorylation of molecules involved in synaptic vesicle exocytosis (SNAP...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Aleksandra Polishchuk, Víctor Cilleros-Mañé, Marta Balanyà-Segura, Laia Just-Borràs, Anton Forniés-Mariné, Carolina Silvera-Simón, Marta Tomàs, Meryem Jami El Hirchi, Erica Hurtado, Josep Tomàs, Maria A. Lanuza
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-07-01
Schriftenreihe:	Cell Communication and Signaling
Schlagworte:	Motor endplate Acetylcholine release Muscarinic receptors BDNF TrkB Serine kinases
Online-Zugang:	https://doi.org/10.1186/s12964-024-01735-2
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