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BDNF/TrkB signalling, in cooperation with muscarinic signalling, retrogradely regulates PKA pathway to phosphorylate SNAP-25 and Synapsin-1 at the neuromuscular junction

Abstract Background Protein kinase A (PKA) enhances neurotransmission at the neuromuscular junction (NMJ), which is retrogradely regulated by nerve-induced muscle contraction to promote Acetylcholine (ACh) release through the phosphorylation of molecules involved in synaptic vesicle exocytosis (SNAP...

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Principais autores: Aleksandra Polishchuk, Víctor Cilleros-Mañé, Marta Balanyà-Segura, Laia Just-Borràs, Anton Forniés-Mariné, Carolina Silvera-Simón, Marta Tomàs, Meryem Jami El Hirchi, Erica Hurtado, Josep Tomàs, Maria A. Lanuza
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2024-07-01
Series:Cell Communication and Signaling
Assuntos:
Motor endplate
Acetylcholine release
Muscarinic receptors
BDNF
TrkB
Serine kinases
Acceso en liña:https://doi.org/10.1186/s12964-024-01735-2
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