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Targeting ErbB3 Receptor in Cancer with Inhibitory Antibodies from Llama

The human ErbB3 receptor confers resistance to the pharmacological inhibition of EGFR and HER2 receptor tyrosine kinases in cancer, which makes it an important therapeutic target. Several anti-ErbB3 monoclonal antibodies that are currently being developed are all classical immunoglobulins. We took a...

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Autori principali: Igor E. Eliseev, Valeria M. Ukrainskaya, Anna N. Yudenko, Anna D. Mikushina, Stanislav V. Shmakov, Anastasiya I. Afremova, Viktoria M. Ekimova, Anna A. Vronskaia, Nickolay A. Knyazev, Olga V. Shamova
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2021-08-01
Serie:Biomedicines
Soggetti:
cancer therapy
monoclonal antibodies
receptor tyrosine kinases
HER3
antibody purification
conformational stability
Accesso online:https://www.mdpi.com/2227-9059/9/9/1106
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