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Targeting ErbB3 Receptor in Cancer with Inhibitory Antibodies from Llama

The human ErbB3 receptor confers resistance to the pharmacological inhibition of EGFR and HER2 receptor tyrosine kinases in cancer, which makes it an important therapeutic target. Several anti-ErbB3 monoclonal antibodies that are currently being developed are all classical immunoglobulins. We took a...

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Principais autores: Igor E. Eliseev, Valeria M. Ukrainskaya, Anna N. Yudenko, Anna D. Mikushina, Stanislav V. Shmakov, Anastasiya I. Afremova, Viktoria M. Ekimova, Anna A. Vronskaia, Nickolay A. Knyazev, Olga V. Shamova
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-08-01
coleção:Biomedicines
Assuntos:
cancer therapy
monoclonal antibodies
receptor tyrosine kinases
HER3
antibody purification
conformational stability
Acesso em linha:https://www.mdpi.com/2227-9059/9/9/1106
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