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Obligate role for Rock1 and Rock2 in adult stem cell viability and function

The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state maintenance of tissues with high turnover such as the blood and intestine. Mutations that alter these processes can cause primary immunodeficiencies, malignancies and defects in barrier function. The R...

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Principais autores: Arivazhagan Sambandam, Elaine Storm, Helen Tauc, Jason A. Hackney, David Garfield, Patrick Caplazi, John Liu, Juan Zhang, Hua Zhang, Jeff Duggan, Surinder Jeet, Sarah Gierke, Patrick Chang, Xiumin Wu, Robert Newman, Lucinda Tam, Tuija Alcantar, Lifen Wang, Meron Roose-Girma, Zora Modrusan, Wyne P. Lee, Heinrich Jasper, Frederic de Sauvage, Rajita Pappu
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2023-03-01
Series:Heliyon
Assuntos:
Rho kinases
Stem cells
Hematopoiesis
Intestinal regeneration
Cytokinesis
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2405844023014457
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