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Obligate role for Rock1 and Rock2 in adult stem cell viability and function

The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state maintenance of tissues with high turnover such as the blood and intestine. Mutations that alter these processes can cause primary immunodeficiencies, malignancies and defects in barrier function. The R...

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Hlavní autoři: Arivazhagan Sambandam, Elaine Storm, Helen Tauc, Jason A. Hackney, David Garfield, Patrick Caplazi, John Liu, Juan Zhang, Hua Zhang, Jeff Duggan, Surinder Jeet, Sarah Gierke, Patrick Chang, Xiumin Wu, Robert Newman, Lucinda Tam, Tuija Alcantar, Lifen Wang, Meron Roose-Girma, Zora Modrusan, Wyne P. Lee, Heinrich Jasper, Frederic de Sauvage, Rajita Pappu
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2023-03-01
Edice:Heliyon
Témata:
Rho kinases
Stem cells
Hematopoiesis
Intestinal regeneration
Cytokinesis
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2405844023014457
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