Excitatory to inhibitory synaptic ratios are unchanged at presymptomatic stages in multiple models of ALS.

Hyperexcitability of motor neurons and spinal cord motor circuitry has been widely reported in the early stages of Amyotrophic Lateral Sclerosis (ALS). Changes in the relative amount of excitatory to inhibitory inputs onto a neuron (E:I synaptic ratio), possibly through a developmental shift in syna...

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Autors principals:	Calum Bonthron, Sarah Burley, Matthew J Broadhead, Vanya Metodieva, Seth G N Grant, Siddharthan Chandran, Gareth B Miles
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2024-01-01
Col·lecció:	PLoS ONE
Accés en línia:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0306423&type=printable
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