Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological symptoms of MDD. Zuranolone (SAGE-217), a neuroact...

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Principais autores:	Keiko Takasu, Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Koichi Ogawa
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2024-01-01
סדרה:	Frontiers in Cellular Neuroscience
נושאים:	neuroactive steroid benzodiazepine extrasynaptic GABAA receptor social defeat stress model antidepressant-like effect theta activity
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1274459/full
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