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Pharmacological modulation of CXCL12/CXCR4/ACKR3 for brain disorders – an overview

Abstract The CXCL12/CXCR4/ACKR3 axis is essential for brain development and homeostasis. Dysregulation of CXCL12 or its receptors has been associated with various CNS disorders related to neurodevelopmental defects, neuroinflammation, neurodegeneration and brain tumors. This signaling axis represent...

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Váldodahkkit: Amandine Kuppens, Bernard Rogister, Virginie Neirinckx
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2026-04-01
Ráidu:Cell Communication and Signaling
Fáttát:
Liŋkkat:https://doi.org/10.1186/s12964-026-02877-1
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